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Vaccination Adverse Reactions COVID-19 API

Provide information to NHS Digital on adverse reactions relating to coronavirus (COVID-19) vaccinations.


Use this API to provide information to us at NHS Digital on adverse reactions relating to coronavirus (COVID-19) vaccinations.

It specifies the flow of information relating to vaccination-related adverse reaction activity from any healthcare setting including:

  • hospital hubs - NHS providers vaccinating on site 

  • local vaccine services – community or primary care led services which could include primary care facilities, retail, community facilities, temporary structures or roving teams 

  • vaccination centres – large sites such as sports and conference venues set up for high volumes of people 

This API specifies the structure and content of the delimited file to send us.

For FHIR standards relating to the flow of information directly back to the patient's GP, see Digital Medicine - FHIR API.

Regulatory reporting

This information flow captures any adverse reactions which occur within the first fifteen minutes after administration of the coronavirus (COVID-19) vaccination. 

At NHS Digital, we must share this information with the Medicines and Healthcare products Regulatory Agency (MHRA) Yellow Card scheme. This scheme is the UK system for collecting and monitoring information on suspected safety concerns or incidents involving medicines and medical devices, including vaccines. 

The information we share with MHRA as part of this scheme is anonymised.

API status

This API is stable.


This API specifies pipe-delimited files sent over MESH.

For more details, see MESH.


This is a Microsoft Word file.  To request a different format, contact us.

Last edited: 1 June 2021 11:32 am