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Creating a new NHS England: NHS England and NHS Digital merged on 1 February 2023. More about the merger.

Vaccination Adverse Reactions COVID-19

Provide information to NHS Digital on adverse reactions relating to coronavirus (COVID-19) vaccinations.


Point-of-care application
Point-of-care applic...
NHS Digital
NHS Digital
send vaccination adverse reaction information
send vaccination adv...
receive vaccination adverse reaction information
receive vaccination adv...
Text is not SVG - cannot display Sends a vaccination-related adverse reactions information in a pipe delimited file from point of care application to NHS Digital.


Use this integration to provide information to us at NHS Digital on adverse reactions.

You can send us information on adverse reactions relating to: 

This integration specifies the flow of information relating to vaccination-related adverse reactions from any healthcare setting including:

  • hospital hubs - NHS providers vaccinating on site 

  • local vaccine services – community or primary care led services which could include primary care facilities, retail, community facilities, temporary structures or roving teams 

  • vaccination centres – large sites such as sports and conference venues set up for high volumes of people 

This integration uses MESH to send pipe-delimited files to us.

For FHIR standards relating to the flow of information directly back to the patient's GP, see Digital Medicine - FHIR.

Regulatory reporting

This information flow captures any adverse reactions which occur within the first fifteen minutes after administration of the coronavirus (COVID-19) vaccination. 

At NHS Digital, we must share this information with the Medicines and Healthcare products Regulatory Agency (MHRA) Yellow Card scheme. This scheme is the UK system for collecting and monitoring information on suspected safety concerns or incidents involving medicines and medical devices, including vaccines. 

The information we share with MHRA as part of this scheme is anonymised.

Who can use this

This integration can only be used where there is a legal basis to do so. Make sure you have a valid use case before you go too far with your development, by contacting us.

You must do this before you can go live (see ‘Onboarding’ below). 


This integration is in production.

Service level

This integration uses MESH which is a silver service, meaning it is operational 24 x 7 x 365 but only supported during business hours (8am to 6pm), Monday to Friday excluding bank holidays.

For more details, see service levels.


This integration specifies pipe-delimited files sent over MESH.

For more details, see MESH.

Network access

This integration is available on the internet and on the Health and Social Care Network (HSCN).

For more details see Network access for APIs.

Security and authorisation

This integration uses MESH which is an application-restricted API.

This integration does not perform any end user authentication or authorisation checks. Rather, the calling system is expected to perform them. 

Environments and testing

This integration uses MESH.

As a developer, you are most likely to want to connect to MESH using either the MESH client or the MESH API.

For more details about using the MESH client, see MESH client.

For the MESH API, there are several independent, externally accessible instances of MESH you can use for testing. For full details, see MESH API - Environments and testing.


You must get your software onboarded before it can go live.

For more details, contact us at


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Last edited: 24 October 2022 5:39 pm