This document aims to provide guidance to clinicians reporting regimen outcomes for non-curative treatments in the systemic anti-cancer therapy (SACT) data set. This guidance was produced with the collaboration of clinicians to address potential differences in interpretation of ‘outcome data’, whilst being mindful of the practicalities of recording this in routine clinical practice.
We appreciate that non-curative treatment benefit assessment is a complex question and may be considered, to a certain extent, subjective. Each patient is unique and ultimately the appreciation of treatment benefit reported is with the clinical staff.
Note that this document focuses only on solid tumours.
The document is made of 3 parts:
- background and introduction
- considerations for assessing benefit
- patient examples
The SACT data set collects data in 4 main areas:
- the patient and their tumour
- where the patient was treated and who initiated their treatment
- treatment details
- clinical outcomes
Treatment outcomes are a key aspect of the SACT data set. The collection of SACT specific outcomes allows the team to design analyses to evaluate treatment effectiveness and identify variations in clinical practice. Additionally, regimen outcome data are reported as part of our work to support Cancer Drugs Fund (CDF) re-appraisals.
‘Treatment outcomes’ refer to the clinical outcomes which result from the administration of a treatment regimen in the SACT data set.
While collecting ‘benefit’ data will likely bring variability at individual level, it is reasonable to expect to see trends at a population level that will be relevant to clinicians, and other groups.
Relevant SACT fields
Intent of treatment
The intent of treatment itself is captured as a separate data item (dataset item 15) and includes curative or palliative options:
National code definition
Curative – aiming to permanently eradicate the disease
Palliative – aiming to extend life expectancy
Palliative – aiming to relieve and/or control malignancy related symptoms
Palliative – aiming to achieve remission
Palliative – aiming to delay tumour progression
Note that multiple answer options can be selected for this item.
The treatment outcomes are captured differently depending on treatment intent:
For curative treatments, (dataset items 57 and 58): clinicians should state whether the treatment was completed as planned (Yes/No). If the treatment was not completed as planned, then further details are required on the reason(s) why the treatment was not completed.
For non-curative treatments, clinicians are asked to specify whether the patient has ‘benefitted’ from receiving the treatment (Yes/No). No further information is required for these treatment outcomes at this stage (dataset item 60). This item is the focus of this guidance document.